abstract：:The persistent use of different forms of nicotine replacement therapy (NRT) is an under-investigated issue in medical research. While the data concerning the proportion of long-term users in the population of total NRT users seems reassuring at first glance, we must recognize that the small relative numbers (proportio...

journal_title：Medical hypotheses

authors： Dome P

更新日期：2011-12-01 00:00:00

abstract：:Hyperplasia of the coronoid process of the mandible has been observed in conditions like Oral submucous fibrosis, TMJ ankylosis, etc. The etiopathogenesis of this coronoid overgrowth has not been clearly sequenced or adequately hypothesized, and no definite mechanism has so far been advocated to explain this elongatio...

journal_title：Medical hypotheses

authors： Chakranarayan A,Jeyaraj P

更新日期：2011-11-01 00:00:00

abstract：:The German doctor Hermann Kümmell described Kümmell's disease as the clinical scenario in which patients suffer a trivial spinal trauma, but develop a symptomatic, progressive, angular kyphosis after a symptom-free period of months to years. Since an intravertebral vacuum phenomenon, which is considered indicative of ...

journal_title：Medical hypotheses

authors： Li H,Liang CZ,Shen CC,Chen QX

更新日期：2011-11-01 00:00:00

abstract：:It has been suggested that dopamine may play an important role in human evolution and adaptive behaviors. Recent studies have revealed an association between the dopamine system and social support among healthy individuals. However, the underlying mechanism remains unclear. In the present study, we propose a dopamine ...

journal_title：Medical hypotheses

authors： Lin SH,Chen PS,Yeh TL,Yang YK

更新日期：2011-11-01 00:00:00

abstract：:Preterm birth is an important perinatal health problem. Several possible mechanisms have been proposed but it may be important to have a testable mechanistic hypothesis that can explain the possible common mechanism for preterm births around the globe. Altered metabolism of micronutrients, like folic acid, vitamin B(1...

journal_title：Medical hypotheses

authors： Sundrani DP,Chavan Gautam PM,Mehendale SS,Joshi SR

更新日期：2011-11-01 00:00:00

abstract：:Vaccines are effective in preventing disease by stimulating the immune system and sustaining an immune response towards eradication of pathogens and diseased cells. However, designing successful vaccines is not always straightforward. For a vaccine to be successful, antigen-presenting cells (APC) need to be stimulated...

journal_title：Medical hypotheses

authors： Ilag LL

更新日期：2011-10-01 00:00:00

abstract：:A wide range of hyperimmune-associated diseases plague post-industrial society, with a prevalence and impact that is staggering. Strong evidence points towards a loss of helminths from the ecosystem of the human body (the human biome) as the most important factor in this epidemic. Helminths, intestinal worms which are...

journal_title：Medical hypotheses

authors： Bilbo SD,Wray GA,Perkins SE,Parker W

更新日期：2011-10-01 00:00:00

abstract：:It is well known, that most of the psychiatric diseases affect various neurotransmitter systems. It is the aim of this profile to define a set of cheap analyses, indicative for a specific psychiatric disease, to facilitate differential diagnosis and to offer an additional tool to the already existing clinical-descript...

journal_title：Medical hypotheses

authors： Niederhofer H

更新日期：2011-10-01 00:00:00

abstract：:Severe affective and behavioral dysregulation, labeled as severe mood dysregulation (SMD), is a widely spread phenomenon among adolescent psychiatric patients. This phenotype constitutes severe impairment across multiple settings, including various symptoms, such as non-episodic anger, mood instability, and hyperarous...

journal_title：Medical hypotheses

authors： Heiler S,Legenbauer T,Bogen T,Jensch T,Holtmann M

更新日期：2011-10-01 00:00:00

abstract：:It is generally accepted that a placebo in a standard, randomized, controlled trial (RCT), being an inert substance, cannot itself produce any effects. Yet, the magnitude of the placebo effect has increased remarkably in the last three decades. We propose that macroscopic information entanglement potentially explains ...

journal_title：Medical hypotheses

authors： Manek NJ,Tiller WA

更新日期：2011-10-01 00:00:00

abstract：:Growing evidences suggest a link between normal tension glaucoma (NTG) and Alzheimer's disease (AD). Both of them are progressive neurodegenerative disorders. Recently researches provide a clue that optineurin may be a new common underlying risk factor involved in NTG and AD. OPTINEURIN (OPTN) gene coding for "optineu...

journal_title：Medical hypotheses

authors： Liu YH,Tian T

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:No method is currently available for preoperative approximation of the patient's situation to the one existing during pneumonectomy in general anesthesia with alternations of single and double-lung ventilation in the lateral position. We hypothesized that a patient breathing the room air in the sitting posit...

journal_title：Medical hypotheses

authors： Subotic D,Ercegovac M,Mandaric D,Herth F,Andric Lj,Gajic M

更新日期：2011-10-01 00:00:00

abstract：:Dental caries, a bacterial process that results in the acidic destruction of tooth structure, has historically been managed by the mechanical excavation of diseased tooth structure and then restoration with a synthetic material. The mechanical excavation of the infected site is most commonly achieved by a dental handp...

journal_title：Medical hypotheses

authors： Quock RL,Patel SA,Falcao FA,Barros JA

更新日期：2011-09-01 00:00:00

abstract：:The review briefly describes the evolution of hypotheses about cronic thyroiditis, the escape of colloid hypothesis, basement membrane destruction, the auto-immune theory and the role of disregulatory genes. ...

journal_title：Medical hypotheses

authors： Stuart A

更新日期：2011-09-01 00:00:00

abstract：:To compensate for the high metabolic costs of lactation, the likelihood of re-impregnation shortly after childbirth is normally reduced due to hormonal changes triggered by breast feeding during the postpartum period. Nowadays, however, bottle feeding as a substitute for breast feeding precludes such changes and leads...

journal_title：Medical hypotheses

authors： Gallup GG Jr,Hobbs DR

更新日期：2011-09-01 00:00:00

abstract：:We describe a six-month-old girl with microcephaly, developmental delay, truncal hypotonia, left pyramidal signs, partial seizures and myoclonic spasms, born to a feverish mother. MRI showed bilateral vascular lesions in the territory of the middle cerebral arteries, prevalent in the right hemisphere, together with hy...

journal_title：Medical hypotheses

authors： Spalice A,Del Balzo F,Papetti L,Nicita F,Ursitti F,Salvatori G,Iannetti P

更新日期：2011-08-01 00:00:00

abstract：:Schizophrenia has a polygenic mode of inheritance and an estimated heritability of over 80%, but success in understanding its genetic underpinnings to date has been modest. Unlike in trinucleotide neurodegenerative disorders, the phenomenon of genetic anticipation observed in schizophrenia or bipolar disorder has not ...

journal_title：Medical hypotheses

authors： Hegde MV,Saraph AA

更新日期：2011-08-01 00:00:00

abstract：:Preliminary reports have suggested that chronic, intermittent electrical stimulation of the cervical vagus nerve (VNS) is an effective treatment for patients who suffered from medically refractory epilepsy. But the traditional VNS is an invasive and implantable procedure that will bring some injury to the patient. Ana...

journal_title：Medical hypotheses

authors： Yang AC,Zhang JG,Rong PJ,Liu HG,Chen N,Zhu B

更新日期：2011-08-01 00:00:00

abstract：:Personality trait research has shown associations with many genes, prominently those of the catecholamine metabolism such as dopamine beta hydroxylase (DBH), catechol-O-methyltransferase (COMT), and monoamine oxidase A (MAOA). Because DBH gene is in linkage disequilibrium with ABO gene, there is reason to think that o...

journal_title：Medical hypotheses

authors： Hobgood DK

更新日期：2011-08-01 00:00:00

abstract：:Current tuberculosis control measures are focused on the prompt detection and treatment of active tuberculosis. Despite the measured success of this strategy, tuberculosis continues to be a public health issue of major significance around the world. This unwanted situation suggests the need to expand our control effor...

journal_title：Medical hypotheses

authors： Mao F,Chen T,Zhao Y,Zhang C,Bai B,Zhao S,Xu Z,Shi C

更新日期：2011-07-01 00:00:00

abstract：:Non-union after bone fracture is rather common with an increasing frequency of incidence rate due to poorly treated early operations, among which the mechanism of atrophic non-union remains unclear. Previous opinions showed that impaired blood supply of affected limbs might mostly contribute to the atrophic non-union,...

journal_title：Medical hypotheses

authors： Sun D,Yuan D,Zhang X

更新日期：2011-07-01 00:00:00

abstract：:Condylar cartilage is absolutely necessary for the normal function of temporomandibular joint (TMJ). Unfortunately, condylar cartilage defect or missing is also one of the common clinical problems. Repair or reconstruction of cartilage is always a hot topic. Cell based cartilage regeneration is suggested as novel ther...

journal_title：Medical hypotheses

authors： Dai J,Wang X,Shen G

更新日期：2011-07-01 00:00:00

abstract：:One area of relative agreement in schizophrenic research is that there is grey matter volume deficit in various cortical areas associated with this illness. One theory attempting to explain this involves an exaggerated action of the normal CNS pruning process. Various aspects of this process were discussed along with ...

journal_title：Medical hypotheses

authors： Rosenthal R

更新日期：2011-07-01 00:00:00

abstract：:Recent evidence suggests that covalent modifications to the genomic platform in the brain, that is DNA and its surrounding histones, provide a stable potentially lifelong mechanism for remembrance. Consequently, the making and unmaking of memories is accessible through pharmacological manipulations of these modificati...

journal_title：Medical hypotheses

authors： Gavin DP,Chase KA,Sharma RP

更新日期：2011-07-01 00:00:00

abstract：:Being born in the winter and spring significantly increases one's risk for developing schizophrenia. This birth seasonality may account for as many as 10% of all cases of schizophrenia. Maternal third trimester infections or vitamin D deficiencies are hypothesized to be the most likely cause and can account for many o...

journal_title：Medical hypotheses

authors： Schwartz PJ

更新日期：2011-06-01 00:00:00

abstract：:Autism, an incurable neurodevelopmental brain disorder, is a complex psychopathology in which the affected individual cannot effectively self-regulate their sensory inputs toward coherent and focused motor outputs. There have been many hypotheses as to the etiology of autism - genetics, neurotransmitter imbalances, ea...

journal_title：Medical hypotheses

authors： Buehler MR

更新日期：2011-06-01 00:00:00

abstract：:Postoperative cognitive dysfunction (POCD) is reported to occur frequently after all types especially cardiac surgery in elderly patients. It can be short-term or long-term and some cases even develop into Alzheimer's disease (AD). Although multi-risk factors associated with POCD have been identified, the etiology and...

journal_title：Medical hypotheses

authors： Fan L,Wang TL,Xu YC,Ma YH,Ye WG

更新日期：2011-05-01 00:00:00

abstract：:The exact nature of the mechanism that triggers initiation of chromosome replication in the best understood of all organisms, Escherichia coli, remains mysterious. Here, I suggest that this mechanism evolved in response to the problems that arise if chromosome replication does not occur. E. coli is now known to be hig...

journal_title：Medical hypotheses

authors： Norris V

更新日期：2011-05-01 00:00:00

abstract：:The staggering number of publications featuring the use of stem cells has revolutionized regenerative medicine research. Preclinical studies indicate that allogeneic human mesenchymal stem cells (MSCs) may be useful for the treatment of several clinical disorders, including sepsis, acute renal failure, acute myocardia...

journal_title：Medical hypotheses

authors： Mamidi MK,Pal R,Govindasamy V,Zakaria Z,Bhonde R

更新日期：2011-04-01 00:00:00

abstract：:Chronic idiopathic axonal polyneuropathy (CIAP) is referred to as axonal neuropathy after an adequate workup fails to determine a cause. A subgroup of patients with CIAP has impaired glucose tolerance (IGT). These patients have been considered by some investigators to have a neuropathy as a result of IGT and/or metabo...

journal_title：Medical hypotheses

authors： Rezania K,Soliven B,Rezai KA,Roos RP

更新日期：2011-04-01 00:00:00

abstract：:An increase in pro-inflammatory cytokines, decrease in endothelial nitric oxide (eNO) and adiponectin levels and an alteration in hypothalamic peptides and gastrointestinal hormones such as incretins and cholecystokinin that regulate satiety, hunger, and food intake occur in metabolic syndrome. Thus, metabolic syndrom...

journal_title：Medical hypotheses

authors： Das UN

更新日期：2011-03-01 00:00:00

abstract：:Skin photoaging, the most common skin damage, is caused by chronic UV irradiation. It is involved in the reduction, aging and apoptosis of fibroblasts (FBs) as well as the blockage of transforming growth factor-beta (TGF-β)/Smad and p38 mitogen-actived protein kinase (MAPK) signaling pathways. Dermal multipotent stem ...

journal_title：Medical hypotheses

authors： Zhong J,Hu N,Xiong X,Lei Q,Li L

更新日期：2011-03-01 00:00:00

abstract：:Intra-peritoneal adhesions ensuing from surgery or infection may lead to chronic pelvic pain, bowel obstruction, infertility and additional invasive surgery to resolve adhesion-related complications. As a result adhesions are a major clinical, social and economic concern. The cumulative year-on-year direct costs of ad...

journal_title：Medical hypotheses

authors： Sadek K,Macklon N,Bruce K,Cagampang F,Cheong Y

更新日期：2011-03-01 00:00:00

abstract：:Physiological levels of estrogen would seem to have a possible protective effect on hearing function and estrogen replacement therapy may delay hearing loss in menopausal women. Treatment of healthy menopausal women with Tibolone for 6 months resulted in improvement in audiometry results at low frequencies which was m...

journal_title：Medical hypotheses

authors： Köşüş N,Köşüş A,Turhan NÖ

更新日期：2011-03-01 00:00:00

abstract：:Genetic and environmental influences are both known to be causal factors in the development and maintenance of obesity. Stress related chronic stimulation of the hypothalamic-pituitary-adrenal (HPA) axis and resulting increased glucocorticoid exposure are known to be important pathophysiological mechanisms in the deve...

journal_title：Medical hypotheses

authors： Mutschler J,Kiefer F

更新日期：2011-03-01 00:00:00

abstract：:Selective serotonin re-uptake inhibitors (SSRIs), has been increasingly used for the treatment of premature ejaculation over the past 5 years. It was reported that folic acid plays important roles in synthesis of 5-HT. Therefore, we hypothesize that folic acid supplementation may cures premature ejaculation by the sam...

journal_title：Medical hypotheses

authors： Yin TL,Yang J,Zhang B,Yan WJ,Xu WM,Li W,Yu L,Li SJ,Wu GX

更新日期：2011-03-01 00:00:00

abstract：:Avascular necrosis of the femoral head (ANFH) is a common ailment characterized by necrosis of bone trabecular and bone marrow. It's mainly caused by the destruction of the blood supply in the femoral head and high rate of morbidity and disability is involved. Many methods have been tried including conservative treatm...

journal_title：Medical hypotheses

authors： Xu M,Peng D

更新日期：2011-02-01 00:00:00

abstract：:Some cancer patients live many decades after diagnosis while others are not so fortunate. Understanding why this occurs is a fundamental issue in cancer research. We hypothesize that among the factors controlling favorable outcome are a class of genes that we describe as "good oncogenes". These genes have a paradoxica...

journal_title：Medical hypotheses

authors： Lee JM

更新日期：2011-02-01 00:00:00

abstract：:Rett syndrome (RTT) is an X-linked dominant postnatal severe and disabling neurodevelopmental disorder which is the second most common cause for genetic mental retardation in girls and the first pervasive disorder with a known genetic basis. The syndrome is primarily caused by mutations in the Methyl CpG binding prote...

journal_title：Medical hypotheses

authors： Ben-Zeev B,Aharoni R,Nissenkorn A,Arnon R

更新日期：2011-02-01 00:00:00

abstract：:Stress, in its many forms, is long associated with the etiology and course of schizophrenia. The mechanisms mediating the impacts of stress are not fully elucidated. Here it is proposed that stress induced cortisol alters kynurenic acid (KA) and quinolinic acid (QA) in the cortex and amygdala/striatum, respectively. T...

journal_title：Medical hypotheses

authors： Anderson G

更新日期：2011-01-01 00:00:00